Another Polish biochemical discovery – heat resistance of native collagen – single helix

The original Polish method of collagen hydration seemed to be defined and its temperature issues unsolvable. Collagen would break down depending on the temperature (read more in this article here)

But we persevered.

Piotr Pakuła, a young successful businessman and a passionate biochemist concentrated on the biochemistry of proteins. This inspired Dr Jan Czarnecki, a researcher into technologies obtaining pharmaceutical components and creator of many drugs, to conduct research. In 2010, at a laboratory in Finepharm Jelenia Gora, Poland. He extracted collagen from fish skins with an almost ideal biological purity. It was not, however, transformed into a marketable product because the problem of breaking it down by colagenase enzymes was not yet solved. This is a highly interesting subject for medicine, especially in orthopaedics. Simultaneously, Dr Czarnecki’s team was looking for a form of fish native collagen which, while maintaining its biological activity, would at the same time increase its heat resistance.

Eventually, such a product was invented!

Dr Czarnecki assumed that maintaining the triple helix conformation in the collagen gel is not a necessary condition for the biological activity of its peptides. He was also the first to scientifically prove that in order for the peptides of the Polish collagen gel to be absorbed, the triple helices must break down on the skin into single spirals (secondary collagen). Ultimately, while on the skin, collagen spirals have to break down into smaller protein chunks to be able to penetrate the skin. Czarnecki’s brilliant idea was to perform a controlled dissimilation of triple spirals into single spirals, while maintaining the gel form of the hydrate.

In 2012 it became possible using a physical, and not chemical method. Utilising kinetics, pressure, and temperature, while maintaining extraordinary precision which is only possible in a perfectly equipped laboratory (formerly “Jelfa” from Jelenia Góra), Dr Czarnecki’s team performed the first completely controlled breakdown of the triple helices into single helices.

Laboratory
Native DNA

Native Collagen Series

In this way, a new, exceptional product was created – Native Collagen. It has the same chemical INCI composition as previous Natural Collagen: Aqua, Collagen, Caprylyl Glycol, Elastin, Lactic Acid.

The New Generation Native Collagens which we are now being introduced, have a few features that the previous triple spiral collagen did not have. Which in turn makes these products much more marketable.

Characteristics of Native Collagens:

  • New native collagen does not denaturise because its despiralisation has already taken place in the process of hydration. Even a transition to a nearly liquid state does not downgrade the value of this product. This is an important innovation.
  • Native collagen gels change their density depending on temperature. The principles of biophysics state that the shorter the spiral construction of the protein, the weaker the water molecule’s binding ability. In low temperatures the density will increase, and in higher temperatures new collagen will approach a semi-liquid, or even liquid, form. However, as opposed to triple spiral collagen, the new collagen will renaturise; when cooled down it will return within a few hours to its previous state. The New Generation Collagen israther well adapted to temperatures below zero, however, itsfreezing can cause (just as in the case of Natural Collagen) the bottle to burst due to expansion of fluids.
  • Organoleptic properties of such collagen will also be slightly different. Though having identical colour, it may possess noticeable lower density and a slightly higher viscosity. Colla genno – “glue-producing” – this is the most characteristic feature of collagen. In the case of new collagen, the effects will be even better. The Finepharma team discovered certain features of lateral hydrogen bonds which bind peptide chains into a single helix. This enabled the creation of a new formulation in such a way that the gel with dynamic density, even liquid (because, e.g., overheated by the user), was not less “collagen”, or not less viscous.
  • This slightly higher viscosity will, after application, frequently give an impression of better lubricating properties and distributes more evenly on the skin. It also has lower volume of lipid residue when compared to previous collagens. Such residue cannot be completely removed in traditional collagen because the fat molecules “get entangled” in triple spiral bonds and mechanical filtration do not eliminate them.
  • Formerly triple spiral collagen, because of lipid residue, had a hint of fish smell. Year by year, the manufacturers have learnt to separate this lipid residue which reduced the fishy smell. Now, the smell of native collagen is subjective. Some like it, some do not. However, any odours evaporate very quickly after application on the skin. The product remains natural, so it contains no artificial fragrances or odour neutralisers.
  • New Generation Native Collagens have better biological purity. They are not only purified from the lipid residues but also from melanin (pigment). Also, smaller protein structures and lower nominal density help to purify the substances still further.
  • New heat-resistant collagen has the pH level ideal for the skin which equals 5.3 whereas the acidity of the triple spiral collagen gel is around to 3.2–3.7 pH. At present, unfortunately, the pH level of Natural Collagen cannot be changed. However, it is worth mentioning that a perfect pH was obtained through ion exchange. This is the biotechnology of the future, which is being developed in Poland.
  • Native Collagen can be easily emulsified with numerous extraordinary components beneficial to the skin. This opens up great possibilities for the product. However the first to be distributed, Native Collagen Pure, does not contain any additives.
  • The new native collagen allows us to use a different type of bottle. Natural Collagen requires a glass packaging. The only company in Europe whose tubes and dispensers do not react with lactic acid is the Italian EuroVetro Cap. For Native Collagen we have contracted the only glass airless bottles in the world from Lumson. They are expensive but also modern and beautiful.

See real results of Collagen Pure treatments

You can use our products not only for everyday treatment for your skin but also to help with some serious skin conditions.